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Bupropion lowers the seizure threshold, with a dose-dependent risk that ranges from 0.1% at standard doses (300 mg/day) to higher rates at very high doses

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Ideal candidates should also be evaluated for their overall health status, ensuring they do not have any contraindications such as a history of pancreatitis, severe gastrointestinal issues, or certain chronic illnesses that could be exacerbated by the medication

Healthcare professionals who encounter patients using unlicensed peptides should approach the conversation without judgement, document use carefully, and consider appropriate baseline investigations including liver function tests, lipid profile, and renal function

Human Sodium Phosphate Transporter 4 (hNPT4/SLC17A3) as a Common Renal Secretory Pathway for Drugs and Urate